Diabetes potentiates the emergence and expansion of antibiotic resistance
Diabetes causes severe skin and soft tissue infections that are resistant to antibiotic treatment. A study found that Staphylococcus aureus SSTIs evolve rapidly in diabetic mice, with diabetes-associated immune cell dysfunction playing a minor role. Hyperglycemia facilitates the expansion of resistant mutants. Insulin control significantly decreased the incidence of antibiotic-resistant S. aureus in diabetic mice.
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